The Hope for African Children Initiative (HACI) is an innovative response that addresses the entire child-focused prevention-care-mitigation continuum with mutually reinforcing program strategies.

The Corridors of Hope (COH) works with transportation corridor communities, targeting traditionally high risk populations. The COH project provides comprehensive HIV/AIDS prevention services and improves referral networks.

Zambia-led Prevention Intiative (ZPI) works to reduce HIV transmission in Zambia through comprehensive, effective, community-based prevention efforts.

PSI/Zambia was established in 1992 to empower at-risk and underserved Zambians to lead healthier lives in line with the Government of Zambia’s health priorities. PSI/Zambia’s current portfolio contains programs in HIV/AIDS, reproductive health, malaria, safe water.

Community COMPACT seeks to prevent new HIV infections by increasing the number of individuals and couples who are aware of their status.The Centre for Infectious Disease Research in Zambia, a research, training, and service provision organisation, implements the program with funding from PEPFAR/CDC.

Wild4Life started as an HIV/AIDS program in Zimbabwe, but has expanded to building rural health systems throughout sub-Saharan African countries. Piloting rural health clinics, monitoring health needs of rural populations and developing local partnerships has dramatically improved health outcomes.

mothers2mothers uses a Mentor Mother Model to empower mothers living with HIV, through education and employment, as role models to help other women access essential services and medical care.

North Star Alliance is a non-profit, public-private partnership that is establishing a network of roadside health clinics at major truck stops and border crossings to serve hard-to-reach populations across Africa.

The Mother-Baby Pack is a take-home box of PMTCT drugs designed for women and children who have limited access to conventional, high-quality preventive care. It contains anti-retroviral drugs and antibiotics to protect one mother and child.

All HIV services, including antiretroviral therapy, are extended to all mothers' HIV-infected children, partners, and other family members. The initiative is known internationally as a model program for family-based care and the early diagnosis and care of infants exposed and infected with HIV.

This project, implemented by Livingstonia Synod AIDS Programme (Lisap) works with volunteers and mobile phones to improve the quality of life of those living with HIV and AIDS.

One Family Health establishes primary healthcare clinics based on franchise principles in areas of need in the developing world, bringing essential medicines and healthcare services to the most vulnerable and underprivileged.