In South Africa, 43.6% of the population resides in rural areas and only 12%doctors and 19% of nurses work in rural areas. Umthombo Youth Development Foundation responds to the need for health professionals in rural areas whee there is dire need for doctors, nurses and other health professionals.

Malamulele Onward is a non-governmental organization established in 2006 that provides rehabilitation services to children affected by cerebral palsy in remote and rural areas. They also provide training to support caregivers and parents of children affected.

Wild4Life started as an HIV/AIDS program in Zimbabwe, but has expanded to building rural health systems throughout sub-Saharan African countries. Piloting rural health clinics, monitoring health needs of rural populations and developing local partnerships has dramatically improved health outcomes.

BroadReach Healthcare's North West Province Down Referral Model in South Africa reduces the reliance on overburdened public health resources by leveraging the private sector in the treatment delivery for people living with HIV/AIDS (PLHA).